Cis and trans-acting elements in somatic hypermutation
نویسندگان
چکیده
1 1.1 Cis-acting elements in somatic hypermutation 3 1.2 Transacting elements in somatic hypermutation 4 1.2.1 Activation-induced cytidine deaminase (AID) 4 1.2.2 Mismatch repair in somatic hypermutation 9 1.3 Mutation rates measurements 13 1.4. Specific Aims 15 1.4.1. Specific aim 1: Develop a retroviral based point mutation indicator system 15 1.4.2. Specific aim 2: Characterize the IgH major intronic enhancer and other enhancer elements, as cis-elements in hypermutation 16 1.4.3. Specific aim 3: Mismatch repair in somatic hypermutation in non-B cells 16
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